Cedric Bouysset

Nice, France · (+33)6 11 99 27 73 · cedric.bouysset@univ-cotedazur.fr

I am a PhD student at the Institute of Chemistry of Nice, in the south of France. My research project tackles taste perception (and sometimes olfaction) using computational approaches. My day-to-day work includes homology modeling of bitter taste receptors, building machine-learning models to predict taste modalities from chemical structures, writing Python or Bash scripts, and a bit of teaching.


Education

Université de Strasbourg, France

Master in Chemoinformatics
Diploma received with honors

GPA: M1 15.1/20 - M2 14.9/20

2016 - 2018

Université de Nice Sophia Antipolis, France

Bachelor in Chemistry
Diploma received with honors

GPA: L1 15.8/20 - L2 14.9/20 - L3 14.5/20

2013 - 2016

Université de Nice Sophia Antipolis, France

First cycle of medical studies
2011 - 2013

Lycée Albert Premier, Monaco

Scientific Baccalaureate
Diploma received with honors
2011

Research

PhD Student and Teaching Assistant

ChemoSim Lab, Institut de Chimie de Nice, UMR 7272, Université Côte d'Azur, France
Subject: Molecular basis of chemosensory perception

Techniques: Molecular modeling, chemoinformatics, machine-learning, molecular dynamics, web-development

October 2018 - September 2021

Internship

ChemoSim Lab, Institut de Chimie de Nice, UMR 7272, Université Côte d'Azur, France

Development of QSAR models for the prediction of several gustative and olfactive properties

February 2018 - July 2018

Internship

IFM Lab, Institut de Science et d'Ingénierie Supramoléculaires, UMR 7006, Université de Strasbourg, France

Calculation of binding affinities of ligand-receptor complexes from MD simulations, using the MM/PBSA approach

March 2017 - June 2017

Internship

Equipe Arômes Parfums Synthèse Modélisation, Institut de Chimie de Nice, UMR 7272, Université de Nice Sophia Antipolis, France

Construction of 3D models of several bitter taste receptors using homology modeling and multiple sequence alignment

June 2016

Experience

Technician

IFM Lab, Institut de Science et d'Ingénierie Supramoléculaires, UMR 7006, Université de Strasbourg, France

Developped ChemFlow, a series of computational chemistry workflows:

  • designed to automatize and simplify the drug discovery pipeline and scoring function benchmarking
  • including extensive data analysis and reporting tools for rapid decision making
  • adapted to work locally or on compute clusters
July 2017 - August 2017

Summer replacement clerk / teller

Customer reception, filing, data entry for banking transactions

Summer 2012 to 2016

Publications

Novel scaffold of natural compound eliciting sweet taste revealed by machine learning

Food Chemistry
Cédric Bouysset, Christine Belloir, Serge Antonczak, Loïc Briand, Sébastien Fiorucci
April 2020
PDF

Machine learning decodes chemical features to identify novel agonists of a moth odorant receptor

Scientific Reports
Gabriela Caballero-Vidal+, Cédric Bouysset+, Hubert Grunig, Sébastien Fiorucci, Nicolas Montagné, Jérôme Golebiowski, Emmanuelle Jacquin-Joly
February 2020
PDF

Metal ions activate the human taste receptor TAS2R7

Chemical Senses
Yi Wang, Amanda L Soohoo, Weiwei Lei, Carol Christensen, Robert F Margolskee, Cédric Bouysset, Jerome Golebiowski, Huabin Zhao, Sébastien Fiorucci, Peihua Jiang
April 2019
PDF

Presentations

9th meeting of the French Chemoinformatics Society

Oral presentation
Title: Decoding sweet taste from chemical structures

November 21, 2019

GDR-O3 2019 annual meeting

Poster
Title: Molecular insights into the structure-function relationships of bitter taste receptors

November 7-8, 2019

European Chemoreception Research Organization annual meeting

Poster
Title: Molecular insights into the structure-function relationships of bitter taste receptors

September 11-14, 2019

26th PACA Chemistry Day

Poster
Title: Modeling taste perception from chemical structures

April 26, 2019

International Perfume Museum project

Public conference
Title: How our brain perceives odors and flavors

Lecture given to middle school students

April 24 & May 15, 2019

21st GGMM congress

Oral presentation
Title: Numerical model of structure-taste relationships

April 5, 2019

2nd UCA Complex Days meeting

Flash talk and Poster
Title: Modeling taste perception from chemical structures

March 25, 2019

Teaching

For first year bachelor students (L1)

Chemical Senses

Lectures and practicals
2019-2020

Microscopic structure of matter

Practicals
2018

Structure and representation of molecules

Exercices
2018-2019

For second year bachelor students (L2)

Chemistry of Solutions

Exercices
2019

Molecular structure and macroscopic properties

Exercices and Practicals
2020


Honours & Awards

  • December 2019 - Laureate of the Université Côte D'Azur Excellence award
  • November 2019 - Best Oral Communication Award - 9th meeting of the French Chemoinformatics Society
  • September 2019 - Laureate of The Gen Foundation grant awarded to students and researchers in natural sciences
  • July 2019 - Travel grant for my participation at the XXIX ECRO Meeting in Trieste, Italy
  • March 2019 - First prize of the best poster during the 'Complex Days' organized by The Complex Systems Academy of Excellence
  • December 2018 - Laureate of the 9th European PhD in Flavor Research Bursaries for first year students by Giract
  • October 2018 - PhD fellowship by the French Ministry of Higher Education and Research

Interests

I spend most of my free-time playing video-games and programing. I am a co-leader of a french speaking team with around 20 members. It involves vocal and game server configuration, competitive training, and participation to some events. I also develop open-source computational chemistry tools such as ProLIF, or ChemFlow.

In the winter, I enjoy snowboarding :snowboarder: The rest of the year, I regularly play badminton with friends.